iLsa Diagnostic Manufacturing and Diagnostics | iDC 20

Automated Liquid Based Cytology System with a throughput of up to 40 slides per hour for providing consistently reproducible mono-cell smear quality with unparalled ease of reading with highest level of economy.

Based on the innovative and classic method of “DOUBLE CENTRIFUGATION” with integrated turbidity measurement to ensure constant and reproducible singe cell smear.

1. Several manual and automated methods are employed for smear preparation including centrifugation, sedimentation, filtration, blotting and depositing.
2. "Liquid based method" allows a thin single layer to be obtained.
3. If abnormal cells are identified, same suspension can be sent to lab for HPV for further processing by molecular biology techniques.
4. Avoids the need for reprocess, and offers better patient care and turn around time.
5. The unique controlled centrifugation process, integrating infra-red detection system incorporated to determine cell concentration and provides consistent results.
6. Ensures REPRODUCIBLE, HOMOGENEOUS, SINGLE CELL quality for optimum cell detection and unparalleled repeatability.
7. Guarantees TOTAL SECURITY AND ZERO RISK contamination, critical needs of the lab.
8. Full traceability from sample to slide assured, without the danger of operator error with complete audit trail.
9. Time tested centrifugation technique, the reference method adopted.
10. Largely eliminates cell debris and parasitic material for better presentation and visualisation needed for diagnosis.
11. Offers "systems approach" for automation with reliable results, and virtually eliminating error prone steps.
12. Complete supply of hardware and consumables with vertical compact shaker accessory for homogenous sample, most compact automated slide stainer, and all relevant consumable covering sample collection and processing steps and as one stop shop.
13. Cells preserved in native condition and non toxic preservative liquid used for processing.
14. Permits usage of sample for immuno histochemical tests without limitation.
15. IDC 20 helps in the preparation of monolayer slides for smear, which can be conveniently read for visual analysis (microscope) or with image acquisition and digital processing via scanner.
16. REAL monolayer slide, offering real monoplane for faster reading
17. The liquid in the vial can be used to perform HPV test on the other instruments for further processing as those from Abbott®, Roche®, Qiagen® and so on, offering higher level of flexibility.
18. Offers a higher level of flexibility in testing
19. The system is well suited for labs handling between 25 to 400 samples per day.
20. Well suited for small to high workloads and at the time same level of economy of operation
21. The realistic cost per sample preparation including the collection set and the dedicated consumables is one of the lowest in the industry and saving a significant amount over a period in the high workload centers.
22. The realistic running cost with IDC20 does not depend on no of samples, and while comparing with systems for similar applications offers BEST life cycle cost.

LBC is a new method for preparing cervical samples for cytological examination. In contrast to the conventional smear preparation, this involves preparation of suspension of cells from sample and used to produce a thin layer of cells on a slide, finds applications in both gynaecological and non gynaecological areas, thyroid, cyst, oral pathology(lesions) for body fluid like urine, pleural effusions, brushing sample (eg. gastrointestinal) tract, lump and FNA (lesions)

1. Overcomes limitations of conventional cytology
2. Future benefits include extra tests- HPV, Chlamydia, Neisseria and Gonorrhea.

Automated liquid based cytology system for a throughput of about 40 slides per hour for providing consistently reproducible mono cell smear equally with ease of reading and economy of cost in a compact table top design.

Features:

1. System shall be controlled by a touch screen with simple interface calling for less than two hours of typical operator training.
2. Preferably based on referral centrifugation principle with facility to ensure constant reproducible single cell smear.
3. Shall be with the process of sample collection from bottle to brush to ensure 100% of the collected cells for the processing.
4. Should have minimal carry over and contamination with disposable tips during the processing for constant quality.
5. High quality slide preparation with no cell clusters, clean cell separation, no deformation with large rectangular spot that shall be homogenous and reproducible as a result of fully automated slide preparation.
6. Shall be suitable for all applications gynaecological and non-gynaecological and smear process, preferably with repeatability of the order of less than 2%.
7. Calculation of cellular concentration by integrated infrared sensor to measure turbidity and thus determine all cell concentration of the sample and then deposit required volume on slide to ensure consistently correct quantity of cells is present on slide.
8. The system process shall be capable of separation to eliminate cell debris and parasitic material like blood, mucus, providing better visualisation of the cells as needed for better diagnosis and reduce the number of unsatisfactory test.
9. System shall ensure real mono layer slide, homogenous and reproducible providing for faster analysis, digitally or with microscope, ensuring real monoplane spreading and avoiding the need for focal adjustment.
10. The system shall ideally involve non toxic preservative liquid for operator safety and safe disposal. Shall employ ethanol with no methanol at all, with a storage period of around two years without sample collection, and 90 days with sample collection.
11. Should permit the usage of liquid in vial also to perform test for HPV by RT-PCR from standard manufacturers.
12. The principle of centrifugation shall be free from the disadvantage of stopping big cells or cellular material resulting in lack of environmental elements or real matrix(mycosis) on the slide.
13. The system configuration shall be free from cell deformation and lacking classification depending on the cell size. It should be possible to handle immuno cyto chemical test with the preserved cells.
14. The LBC device shall involve not more than five minutes of hands on time to process a batch of 20 samples loaded for analysis, providing a throughput of 40 slides in an hour approximately.
15. Total security with full traceability from bottle to slide and bar-coded recognition before sample distributed with flagging of any operator error.
16. Full traceability with all data storage and accessible in simple excel file.
17. Vertical shaker accessory to separate heap of cell to dissolve mucus, and adaptable to different bottle sizes and effective to obtain a homogenous fluid smear to handle at least 40 specimen bottles per run.
18. System shall be supplied complete with one additional set of accessories for processing when system is in operation. Appropriate automated freely programmable stainer for handling at least 10 slides simultaneously can be quoted under option separately as per broad specifications attached.

System should permit being fitted with optional GSM device to provide remote and real time consumption read out, to facilitate easy stock management of consumables and also aid in automatic stock replenishment.

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