1. How does ESR level affect lipoprotein?  

    ESR is a non specific measurement and it is not directly linked to either lipoprotein or triglycerides. 

    Certain proteins associated with a variety of disease conditions, may stick to the red  cells and cause  
    them to clump together and fall faster. This can result in falsely elevated ESR results.

 2. How are the results affected by triglycerides, and haziness especially in milky plasma samples?

     Haziness is due to fatty substances in sample, and makes the red cell interface difficult to determine,
     when reading the ESR, in general.

StaRRsed overcomes this problem by accurately measuring the mid point of the hazy area, which is
very difficult to detect by naked eye, or even by methods employed by other machines. In view of this, 
the system tends to give the best estimate of the real ESR, despite presence of haziness, due to fatty
substances.

 3.  What is the impact of improper dilution in EDTA tubes and how does it affect ESR ?

Variation in the 1:4  dilution will cause the measured ESR to change, but not to a great extent. 
StaRRsed machine automatically dilutes the sample with accuracy better than 1%. This would
give much better results than can be achieved with prefilled citrated blood collection tubes, 
which are employed in most other machines.

 4.  What is the validation process involved with the Mechatronics ESR?

The Westergren method, as used on all the StaRRsed ESR analysers, fromMechatronics, continues
to be the method recommended by International Committee for Standardisation in Haematology. 
ICSH recommendation for measurement of erythrocyte sedimentation rate, as per reference,
J. Clin Path 1993 46 198-203, copy of article enclosed.